Publications

Preprints (1)
71. Juusola, M., Dau, A., Song, Z., Solanki, N., Rien, D., Jaciuch, D., Dongre, S., Blanchard, F., de Polavieja, G.G., Hardie, R.C. & Takalo, J. (2016). Microsaccadic information sampling provides Drosophila hyperacute vision.

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Peer-Reviewed Original Articles Accepted, in Print or in Press (56)
70. Friederich, U., Billings, Hardie, R.C., Juusola, M. & Coca, D. (2016). Fly photoreceptors compute phase congruency. PLoS one 11(6): e0157993

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69. Song, Z., Zhou, Y. & Juusola, M. (2016). Random photon absorption model elucidates how early gain control in fly photoreceptors arises from quantal sampling. Front. Comput. Neurosci. 10 (61): 1-13.

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68. Dau, A., Friederich, U., Dongre, S., Li, X., Bollepalli, M.K., Hardie, R.C. & Juusola, M. (2016). Evidence for dynamic network regulation of Drosophila photoreceptor function from mutants lacking the neurotransmitter histamine. Front Neural Circuits 10 (19): 1-22.

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67. Juusola, M., Dau, A., Zheng, L. and Rien, D. (2016). Electrophysiological method for recording intracellular voltage responses of Drosophila photoreceptors and interneurons to light stimuli in vivo. J. Vis. Exp. 112: e54142.

Jove Video

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66. Randall AS, Chu B, Liu C-H, Zhang Q, Dongre S, Juusola M, Wakelam M, Franze K & Hardie RC (2015). Speed and sensitivity of phototransduction in Drosophila depend on degree of saturation of membrane phospholipids. J Neurosci 35: 2731-2746.

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65. Song Z & Juusola M (2014). Refractory Sampling Links Efficiency and Costs of Sensory Encoding to Stimulus Statistics. J Neurosci 34: 7216 –7237.

  • Demonstrates that fly photoreceptors are biophysically tuned, through stochastic refractory photon sampling by their microvilli, to transmit naturalistic stimuli with high information rates and that this encoding process is efficient from an energetics standpoint

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64. Li M, Liu F, Juusola M & Tang S (2014). Perceptual color map in macaque visual area V4. J Neurosci 34: 202-217.

  • Shows how 3-D perceptual colour space in represented as a 2-D projection (colour-map) on the cortex; reflecting colour hue-saturation-lightness coordinates
  • Combinatorial distributed coding to expand the cortical colour space

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63. Heimonen K, Immonen E-V, Frolov R, Salmela I, Juusola M, Vähäsöyrinki M & Weckström M (2012). Signal coding in cockroach photoreceptors is tuned to dim environments. J Neurophysiol 108: 2641-2652.

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62. Song Z, Postma M, Billings SA, Coca D, Hardie RC & Juusola M (2012). Stochastic, Adaptive Sampling of Information by Microvilli in Fly Photoreceptors. Curr Biol 22: 1371-1380.

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61. Wardill TJ, List O, Li X, Dongre S, McCulloch M, Ting CY, O’Kane CJ, Tang S, Lee CH, Hardie RC & Juusola M (2012). Multiple Spectral Inputs Improve Motion Discrimination in the Drosophila Visual System. Science 336: 925-931.

  • Refutes 30-year old hypothesis that colour and motion pathways in insect eyes would be independent
  • Science Signaling: Editors’ Choice
  • Supplement

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60. Lipscomb L, Parkin CA, Juusola M & Winder SJ (2011). The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish. PLoS Currents: Muscular Dystrophy. 3: RRN1286.

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59. Abou Tayoun AN, Li X, Chu B, Hardie RC, Juusola M & Dolph PJ (2011). The Drosophila SK channel (dSK) contributes to photoreceptor performance by mediating sensitivity control at the first visual network J Neurosci 31: 13897-13910.

  • Shows how homeostatically balanced synaptic network functions can compensate missing or faulty ion channels in visual information processing

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58. Gonzalez-Bellido PT, Wardill TJ & Juusola M (2011). Compound eyes and retinal information processing in miniature dipteran species match their specific ecological demands. Proc Natl Acad Sci USA 108: 4224-4229.

  • Discovery of the evolutionary adaptations that allow miniature compound eyes to operate efficiently despite their optics approaching diffraction limit
  • Chosen for PNAS media report: http://www.pnas.org/site/misc/selections_2_21_11.shtml#eyes
  • Won International Society for Neuroethology Capranica Prize in recognition of a paper judged to be most scientifically significant in the field of Neuroethology in 2010

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57. Tang S & Juusola M (2010). Intrinsic Activity in the Fly Brain Gates Visual Information during Behavioral Choices PLoS one 5(12): e14455.

  • 1st electrophysiological evidence that the fly brain highlights chosen information while ignoring the irrelevant, similar to what we know to occur in higher animals

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56. Gonzalez-Bellido PT, Wardill TJ, Kostyleva R, Meinertzhagen IA & Juusola M (2009). Overexpressing Temperature-Sensitive Dynamin Decelerates Phototransduction and Bundles Microtubules in Drosophila Photoreceptors J Neurosci 29: 14199-14210.

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55. Nikolaev A, Zheng L, Wardill TJ, O'Cane CJ, de Polavieja GG & Juusola, M (2009). Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: II mechanisms PLoS one 4(1): e4306.

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54. Zheng L, Nikolaev A, Wardill TJ, O'Cane CJ, de Polavieja GG & Juusola M (2009). Network adaptation improves temporal representation of naturalistic stimuli in Drosophila eye: I dynamics PLoS one 4(1): e4307.

  • 1st direct electrophysiological evidence of how network adaptation affects neural coding of visual signals in the Drosophila eye
  • Shows how dynamic adjustment of both frequency and amplitude of the output signal improves sensitivity and signal-to-noise ratios
  • The adjustments include the use of previous encounters with the temporal structure of the images to improve the operating range of the output signal

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53. Pantazis A, Segaran A, Liu C-H, Nikolaev A, Rister J, Thum A, Roeder T, Semenov E, Juusola M, Hardie RC (2008). Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse. J Neurosci 28: 7250-7259.

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52. Faivre OC & Juusola M (2008). Visual coding in locust photoreceptors. PLoS one 3(5): e2173.

  • 1st to demonstrate that the graded photoreceptor output to naturalistic light intensity time series is normalised over frequency to provide invariance for early visual coding
  • Selected as an example of quality in Neuroscience/Cognitive Science/Machine Vision papers in PLoS ONE by the Scientific Editors of the Journal
  • We were interviewed by the journal: http://www.plos.org/cms/node/386

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51. McQuibban GA, Lee JR, Zheng L, Juusola M & Freeman M (2006). Rhomboid-7 regulates mitochondrial dynamics and contributes to Drosophila lifespan and neuronal function. Curr Biol 16: 982-989.

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50. Zheng L, de Polavieja GG, Wolfram W, Asyali MH, Hardie RC & Juusola M (2006). Feedback network controls photoreceptor output at the layer of first visual synapses in Drosophila. J Gen Physiol 127: 495-510.

  • 1st to quantify the contribution of feedback synapses in neural information processing

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49. Vähäsöyrinki M, Niven JE, Hardie RC, Weckström M & Juusola M (2006). Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels. J Neurosci 26: 2652–2660.

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48. de Polavieja GG, Harsch A, Kleppe I, Robinson HPC & Juusola M (2005). Stimulus history reliably shapes action potential waveforms of cortical neurons. J Neurosci 25: 5657-5665.

  • 1st to quantify that action potential waveforms carry information
  • Highlighted article, accompanied by an extra editorial from the Scientific Editors of the Journal

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47. Asyali MH & Juusola M (2005). Use of Meixner functions in estimation of Volterra kernels of nonlinear systems with delay. IEEE Trans Biomed Eng 52: 229-237.

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46. Wolfram W & Juusola M (2004). The impact of rearing conditions and short-term light exposure on signaling performance in Drosophila photoreceptors. J Neurophysiol 92: 1918-1927.

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45. Niven JE, Vähäsöyrinki M, Juusola M & French AS (2004). Interaction between light induced currents, voltage-gated currents and input statistics in Drosophila photoreceptors. J Neurophysiol 91: 2696-2706.

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44. Juusola M, Niven JE & French AS (2003). Shaker K+ channels contribute an early nonlinear amplification to the light response in Drosophila photoreceptors. J Neurophysiol 90: 2014-2021.

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43. Juusola M & de Polavieja GG (2003). The rate of information transfer of naturalistic stimulation by graded potentials. J Gen Physiol 122: 191-206.

  • 1st method to calculate the rate of information transfer for any signalling system without assumptions
  • 1st to quantify neural adaptation in graded potential neurones to naturalistic stimuli

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42. Niven JE, Vähäsöyrinki M & Juusola M (2003). Shaker K+ channels are predicted to reduce the metabolic cost of neural information in Drosophila photoreceptors. Proc R Soc Lond B 270: 58-61.

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41. Niven JE, Vähäsöyrinki M, Kauranen M, Hardie RC, Juusola M* & Weckström M (2003). The contribution of Shaker K+ channels to the information capacity in Drosophila photoreceptors. Nature 421: 630-634. (* the corresponding author)

  • 1st to quantify the contribution of single ion channels to the neuronal rate of information transfer

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40. Hardie RC, Martin F, Cochrane GR, Juusola M, Georgiev P & Raghu, P (2002). Molecular Basis of amplification in Drosophila phototransduction: roles for G protein, phosphlipase C and diacylglycerol kinase. Neuron 36: 689-701.

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39. Hardie RC, Raghu P, Moore S, Juusola M, Baines R & Sweeney S (2001). Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron 30: 149-159.

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38. Juusola M & Hardie RC (2001). Light-adaptation in Drosophila photoreceptors: II Rising temperature increases the bandwidth of reliable signalling. J Gen Physiol 117: 27-42.

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37. Juusola M & Hardie RC (2001). Light-adaptation in Drosophila photoreceptors: I Response dynamics and signaling efficiency at 25oC. J Gen Physiol 117: 3-25.

  • Introduces a new in vivo Drosophila preparation, intracellular recording system around it and data acquisition and analysis software (BIOSYST)
  • Revolutionises the use of Drosophila for system-analytical vision research

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36. Marmarelis VZ, Juusola M & French AS (1999). Principal dynamic mode analysis of nonlinear transduction in a spider mechanoreceptor. Ann Biomed Eng 27: 391-402.

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35. Juusola M & French AS (1998). The adaptation properties of two types of sensory neurons in a spider mechanoreceptor organ. J Neurophysiol 80: 2781-2784.

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34. Korenberg MJ, Juusola M & French AS (1998). Two methods for calculating the responses of photoreceptors to moving objects. Ann Biomed Eng 26: 308-314.

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33. Juusola M & French AS (1997). Efficiency of sensory information coding by mechanoreceptor neurons. Neuron 18: 959-968.

  • 1st to quantify the loss of information when graded potentials is converted to digital action potentials
  • Uses a novel recording/stimulation apparatus, software systems and an isolated mechanoreceptor organ preparation

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32. Juusola M, Seyfarth EA & French AS (1997). Rapid coating of class-capillary microelectrodes for single-electrode voltage-clamp. J Neurosci Meth 71: 199-204.

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31. Juusola M & French AS (1997). Visual acuity for moving objects in first and second order neurons of the fly compund eye. J Neurophysiol 77: 1487-1495.

  • 1st to systematically test and predict the visual acuity of fly photoreceptors and visual interneurons using nonlinear spatiotemporal functions extrapolated from the responses to complex dynamic stimulation

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30. Juusola M, Weckström M, Uusitalo RO, Korenberg M & French AS (1995). Nonlinear models of the first synapse in the light-adapted fly retina. J Neurophysiol 74: 2538-2547.

  • 1st dynamic nonlinear models of signal transfer in fly photoreceptor-interneuron synapses

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29. Juusola M & French AS (1995). Transduction and adaptation in spider split sense organ mechanoreceptors. J Neurophysiol 74: 2513-2523.

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28. Juusola M & French AS (1995). Recording from cuticular mechanoreceptors during mechanical stimulation. Pflüger Arch 431: 125-128.

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27. Uusitalo RO, Juusola M, Kouvalainen E & Weckström M (1995). Tonic transmitter release in a graded potential synapse. J Neurophysiol 74: 470-473.

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26. Uusitalo RO, Juusola M & Weckström M (1995). Graded and spiking responses in identified first order visual interneurons of the fly compound eye. J Neurophysiol 72: 1782-1792.

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25. Weckström M, Juusola M, Uusitalo RO & French AS (1995). Fast-acting compressive and facilatory nonlinearities in light-adapted fly photoreceptors. Ann Biomed Eng 23: 70-77

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24. Juusola M, Uusitalo R & Weckström M (1995). Transfer of graded potentials at the photoreceptor-interneuron synapse. J Gen Physiol 105: 117-148.

  • 1st to quantify in frequency domain how synaptic adaptation improves information processing

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23. Juusola M, Seyfarth EA & French AS (1994). The sodium-dependent receptor current in a new mechanoreceptor preparation. J Neurophysiol 72: 3026-3028.

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22. Kouvalainen E, Weckström M & Juusola M (1994). Determination of signal-to-noise ratio and linearity in light-adapted blowfly photoreceptors. Vis Neurosci 95: 1221-1225.

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21. Juusola M, Kouvalainen E, Järvilehto M & Weckström M (1994). Contrast gain, signal-to-noise ratio and linearity in light-adapted blowfly photoreceptors. J Gen Physiol 104: 593-621.

  • 1st to apply white-noise contrast stimulus for studying neural adaptation in photoreceptors

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20. Juusola M (1994). Measuring complex admittance and receptor current by single electrode voltage-clamp. J Neurosci Meth 53: 1-6.

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19. French AS, Korenberg M, Järvilehto M, Kouvalainen E, Juusola M & Weckström M (1993). The dynamic nonlinear behavior of fly photoreceptors evoked by a wide range of light intensities. Biophys J 65: 832-839.

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18. Juusola M & Weckström M (1993). Band-pass filtering by voltage-dependent membrane in an insect photoreceptor. J Neurosci Lett 154: 84-88.

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17. Juusola M (1993). Linear and non-linear contrast coding in light adapted blowfly photoreceptors. J Comp Physiol A 172: 511-521.

  • Shows how the early rising or decaying phase of a fly photoreceptor's voltage responses is the most robust representation of the light contrast changes, implying phase coding
  • Shows that the voltage-dependent K+-channels of the plasmamembrane cannot be the cause for the major compressive nonlinearity in the responses but that this must happen earlier, at the level of phototransduction current

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16. Weckström M, Juusola M & Laughlin S (1992). Presynaptic enhancement of signal transients in photoreceptor terminals in the compound eye. Proc R Soc B Lond 250: 83-89

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15. Weckström M, Kouvalainen E & Juusola M (1992). Measurement of cell impedance in frequency domain using discontinuous current clamp and white noise modulated current injection. Pflüger Arch 421: 469-472.

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Peer-Reviewed Review Articles (5)
14. Juusola M & Song Z (2017). How a Fly Photoreceptor Samples Light Information in time. J Physiol Lond (accepted)

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13. Song Z & Juusola M (2017). A biomimetic fly photoreceptor model elucidates how stochastic adaptive quantal sampling provides a large dynamic range. J Physiol Lond (accepted)

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12. Hardie RC & Juusola M (2015). Phototransduction in Drosophila. Curr Opin Neurobiol 34: 37-45.

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11. Juusola M, Robinson HPC & de Polavieja GG (2007). Coding with spike shapes and graded potentials in cortical networks. BioEssays 29: 178-187

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10. Juusola M, French AS, Uusitalo RO & Weckström M (1996). Information processing by graded potential transmission through tonically active synapses. Trends Neurosci 19: 292-297.

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Book Chapters and Peer-Reviewed Conference Proceedings (8)
9. Juusola M, Song Z & Hardie RC (2015). Phototransduction biophysics. Encyclopedia of Computational Neuroscience, Springer-Verlag. pp 2359-2376.

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8. Friederich U, Billings SA, Juusola M & Coca D (2012). Reverse Engineering Gain Adaptation in Sensory Systems. Acta Press, Proceedings of the 9th IASTED International Conference on Biomedical Engineering, doi:10.2316/P.2012.764-125.


7. Song Z, Billings S, Coca D, Postma M, Hardie RC & Juusola M (2009). Biophysical Modeling of a Drosophila Photoreceptor Lect. Notes Comp. Sci. (ICONIP 2009, Part I) 5863: 57–71


6. Friederich U, Coca D, Billings S & Juusola M (2009). Data Modelling for Analysis of Adaptive Changes in Fly Photoreceptors Lect. Notes Comp. Sci. (ICONIP 2009, Part I) 5863: 34–48


5. de Polavieja GG, Harsch A, Robinson HPC & Juusola M (2005). Slow conductances encode stimulus history into spike shapes. Lect. Notes Comp. Sci. 3561: 150-155.


4. Weckström M, Juusola M & Uusitalo RO (2000). Synaptic signal transfer in the graded potential synapse. In Neuroscience Finland 1999. Invited lectures and abstracts of short communications. (ed. Weckström, M.). Acta Universitatis Ouluensis, Medica. pp. 25-29.


3. Juusola M & French AS (1998). Signal encoding in spider slit-sense organ mechanoreceptor neurons. In From structure to information in sensory systems (eds. Teddei-Ferretti C. & Musio C). pp. 254-265. World Scientific, Singapore, New Jersey, London, Hong Kong. 30.


2. Juusola M, Uusitalo RO & Weckström M (1998). Optimizing the flow of information by early visual processing. In From structure to information in sensory systems (eds. Teddei-Ferretti C. & Musio C). pp. 412-430. World Scientific, Singapore, New Jersey, London, Hong Kong. 29.

Books (1)
1. Juusola, M. (1993) Contrast coding in dipteran photoreceptors, the role of phototransduction and the cell membrane. Acta Univ. Oulu 142 pp. ISBN 951-42-3629-7; ISSN 0355-3221